Comparison between Hydroxyapatite-Alginate and Whitlockite Alginate Nano composites as Drug delivery matrix for sustained release of Ciprofloxacin

Abstract

For bone tissue engineering and bone remodelling, functional biomaterials that connect the processes of angiogenesis and osteogenesis are essential. The presence of nanoparticles in polymers results in the creation of polymeric nanocomposites, which increase the characteristics of the nanoparticles and polymer. It is feasible to enhance the osteoinductive and osteoconductive properties of the bones by utilising ceramic materials like nHA (nano hydroxyapatite) and nWH (nano-whitlockite). According to literature the most prevalent inorganic phases in the skeletal tissues are HA and WH. Comparison between nano hydroxyapatite (nHA) and whitlockite (nWH) nanocomposite beads for sustained release of drug ciprofloxacin for bone tissue regeneration is elucidated in this project. Morphology, crystallinity, degradation and drug release studies of composites were carefully assessed. Briefy, nHA and nWH nanoparticles were synthesized by wet chemical precipitation method and further carried out by drug loading procedures in which the drug was absorbed on to the nHA and nWH surfaces. Different compositions were made by varying the drug loading percentages. Chemical analysis of the prepared nanoparticles and composites was carried out using X-ray Diffraction (XRD), Fourier Transform infrared spectrophotometry (FTIR), and Raman Analysis. Results of composites conclude that nHA and nWH were carefully inserted into the polymer matrix and remained well intact with the alginate macromolecules. Research has been conducted on the loading and release of drugs. Prior to the composite's formation, the drug ciprofloxacin was pre-adsorbed onto the ceramic particles. Results confirmed that the nanocomposites prepared under optimum condition prolonged the release of ciprofloxacin which hold a great benefit in bone tissue engineering. Hence it was proved that both of the ceramic materials Hydroxyapatite and Whitlockite can be used to improve the efficacy of bone regeneration and could be a good candidate for bone tissue engineering.