Abstract:
Breast cancer is one of the most prevalent cancer among women globally with higher
metastatic potential and recurrence rate leading to greater mortality rates in females of
Pakistan which demands for a promising prognostic biomarker of breast cancer to make
early detection possible. KLF17 is a transcription factor and has been observed to play
important role as tumor suppressor specifically inhibiting EMT but protein has received
little consideration in perspective of Single Nucleotide Polymorphism. Therefore, the aim
of this study was to analyze the pathogenic variants of KLF17 and its association with
breast. The SNPs in KLF17 effect both the structure and function of KLF17 was
investigated through in-silico analysis and the results observed were validated through the
blood-based genotypic analysis via ARMS PCR. A positive association of C345R SNP
was observed with pathogenesis of breast cancer, suggesting that rs183242786 could be
used as a prognostic biomarker of Breast Cancer.
