Abstract:
This study explores the protective effects of Saikosaponin B2, a triterpenoid extracted from
the roots of Radix bupleurum against lipopolysaccharide-induced inflammation, a common
model for studying neurodegenerative diseases. LPS induces strong immune reactions,
activating pro-inflammatory cytokines, increases ROS generation, ultimately leading to
neuronal damage and loss. We theorized that Saikosaponin B2 holds an anti-inflammatory
and anti-oxidant profile capable of mitigating LPS-induced effects. An in-vitro model was
used to determine the extract’s effectiveness in reducing inflammatory gene expression,
ROS generation and activation of injury mechanisms. Our results show that Saikosaponin
B2 reduces LPS-induced inflammation, signifying its possible utilization as a therapeutic
agent against neurodegenerative diseases.
