Abstract:
There has been a surge in interest recently in the creation of innovative materials and
therapeutic strategies to enhance the results of wound healing for chronic wounds as it is
a painful condition that entails complex healing phenomena and would take years to
recover. Hence, the use of nanoparticles to promote wound healing through cell
proliferation and antimicrobial activity has proved to be an efficient way to increase the
healing process. For this, a multipurpose smart dressing material with a variety of qualities
that can encourage the best possible wound healing is required. This work used a PVA/HA
biodegradable matrix for wound healing that used glycerin as a plasticizer and reinforced
with AgNPs and MOF-199, to develop a smart nanocomposite hydrogel membrane.
Different characterization techniques XRD, FTIR, SEM and mechanical testing were
carried out to examine the membrane's shape and structural characteristics. Additionally,
to assess the membrane's efficacy as a wound healing material, biomedical tests were
carried out like moisture retention, gel fraction, swelling and antimicrobial. The
membrane formed was hydrophilic, with excellent swelling properties and reasonable gel
fraction and moisture retention values. It also showed remarkable mechanical strength and
flexibility. These findings imply that the membrane created has promise for use as an
efficient material for treating wounds and can prove be a good dressing for medium to
high exudate absorption due to MOF-199 high surface area and porosity.
