A natural product Decursin enhances the radio- sensitization of IR against DMBA-induced tumor

Abstract

In healthy cells signaling networks control key functions and the overall fate of the cell and are activated through a myriad of signals from the extracellular and the intracellular environment. In cancerous cells however, these signaling networks are disrupted as a result of mutations or genetic alterations. These mutations interfere with the normal signaling and cause Radio-resistance. Recent advances in cancer therapeutics are aimed at targeting these pathways through inhibition of various molecules e.g. tyrosine kinase inhibitors are used to target kinases. Decursin is the active coumarin compound, isolated from the roots of Angelica gigas Nakai (Umbelliferae) and exhibits anti-inflammatory activities. We hypothesized that the anti-inflammatory activity of Decursin will consecutively contribute to its radio-sensitization effect, when administered together with radiation therapy. The western blot results showed that Decursin together with ionizing radiation, inhibited the p52 subunit of NF-κB and also inhibited the degradation of IκB. Decursin also lead a decrease in the expression of P-Akt. Tumor volume was also monitored and showed a decrease over the period of treatment.