SYNTHESIZATION AND CHARACTERIZATION OF NATURAL BIOCOMPATIBLE COMPOSITE HAVING SUSTAINED DRUG RELEASE MECHANISM FOR TOPICAL AND SUBCUTANEOUS APPLICATIONS

Abstract

The study focuses on the development of a novel natural biocompatible composite with an ability to release drug at a constant rate. Topical drug delivery being used now a days has yet to achieve its potential in place of oral drug delivery and injections. Basil seed gum having absorption property has been used for many pharmaceutical applications. CMC and PVA being biocompatible, has been used for wound dressing for a decade. In this project, the composites in the ratios PVA/Gum 1:3, CMC/Gum 3:1, CMC/PVA/Gum 3:1:3 were synthesized. Swelling analysis of these composites was done along with characterization through FTIR, XRD, SEM and tensile testing. Hermal seed extract was incorporated in the composites because of its antimicrobial and anti-inflammatory property. Also, the in vitro testing was done to evaluate the drug release profile and anti-bacterial activity of the composite. The CG31-H composite showed uniform uptake of PECF solution and sustained release of hermal extract while in PG13-H and CPG313-H composites the swelling and release of drug started decreasing. The mechanical testing revealed that the composite having PVA have good tensile strength. Therefore, these composites can be used for wound dressing as it contains natural anti-bacterial agent to counter the antibiotic resistant bacteria.