Effect of Non-Invasive Neuro-Stimulation and Dietary Boosted Dopamine Levels in MPTP Induced Parkinson Mice Models

Abstract

Parkinson‟s disease (PD) is one of the leading neurodegenerative disorders which involve degeneration of the dopaminergic neuron due to oxidative stress. The Centella asiatica whole plant extract (CAE) has been reported efficient as an anti-oxidant raising the glutathione levels in Balb/c mice model. Transcranial Direct Current Stimulation (tDCS) has also been approved effective for PD therapy in recent years. The present study was designed to investigate the effects of tDCS and CAE on the oxidative stress in mice model of PD induced by1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP).The animals were modulated by tDCS and orally treated with CAE. Behavioral alterations were observed after three weeks based on pole, grid and swim test. The mice were sacrificed for the measurement of the level of dopamine (DA) and reduced glutathione (GSH) in the brain and serum. The mice treated with MPTP had a reduced level of DA and decreased GSH activity, as well as behavior impairments.