Design and Development of Drug Eluting Stent Graft for the Treatment of Coronary Diseases

Abstract

Novel curcumin loaded polyvinyl alcohol (PVA) nanofibrous mats were fabricated using single nozzle electrospinning technique. Curcumin, an antioxidant and anti-microbial drug was incorporated in PVA which is a synthetic, nontoxic and biodegradable polymer. Combination of the two components was used to get an added benefit for the prevention of late in-stent restenosis. Fixed ratios of curcumin and PVA were used for the production of polymeric films. Antioxidant activity of the polymeric films was evaluated and films with highest concentration of the curcumin showed highest antioxidant activity. Antimicrobial activity was tested against E. coli, P. aeruginosa and MRSA and the composition with lowest curcumin content (0.65%) showed highest activity of all compositions. In vitro drug release and degradation profiles were also evaluated. The degradation and drug release results suggested the composition with 0.65% curcumin to be the best for use in the treatment of coronary artery disease along with the use of DES. The study concluded the electrospun mats to have potential use in the treatment of post-stent complications i.e. delayed endothelialization and late in-stent restenosis.