‘Development of UV Stabilizing Biomedical Textile by LbL Coating of Tinuvin-622 Polymeric Nanoparticles

Abstract

The purpose of this research was to formulate a protocol to develop a low cost, easily manufactured UV Stabilizing cotton textile by coating polymeric nanoparticles of PCL encapsulating a light stabilizer, HALS. HALS was coated with PCL to form nanoparticles which were suspended in a liquid formulation of a homogeneous solution of Tween-80 and Deionized water. Various parameters such as drug concentration, polymer concentration, surfactant concentration, organic solvent concentration, temperature, stirring speed and stirring time were varied to find the most stable and homogeneous drug loaded formulation. The best optimized formulation was then diluted and coated on industrially obtained cotton textile in combination with PDADMAC solution by using LbL coating method. Further characterization by Optical Microscopy, Scanning Electron Microscopy, Particle Size Analysis and Zeta Potential, UV Spectrophotometry, Fourier Transform Infra-Red Analysis, UV-Vis-NIR Spectrophotometry and UPF testing were performed on the emulsion as well as textile. The most stable emulsion showed a hazy appearance, with an average particle size of 200 nm, poly Dispersity Index of 0.13, zeta potential of -19. SEM results showed the formation of spherical nano-capsules and FTIR analyses showed the bonds found on the surface of the nanoparticles and the textile confirming the coating of polymer. UV spectrophotometric analysis at 215 nm showed an encapsulation efficiency of 84%. UPF testing showed a UPF value of 30.65 which is appropriate with respect to the application.