Calibration and Testing of Electronically Controlled Drug Delivery Device for the Treatment of Acute Wounds

Abstract

With the unprecedented progress of biomedical engineering during the past few decades, conventional drug delivery systems have been evolved into smart drug delivery systems with stimuli-responsive characteristics. Bene ting from the response to speci c internal or external triggers, those well-de ned platforms can increase the drug targeting e cacy, in the meantime, reduce side e ects/toxicities of payloads, which are key factors for improving pa- tient compliance. The system described in this study, is a wearable patch consisting of a drug reservoir that is integrated with electromechanically ac- tuated programmable drug dispensation mechanism which can release ac- tive pharmaceutical compound in a controlled fashion. It works primarily on the principle of active Drug Delivery through Electromechanical based techniques. The proposed model of device houses the drug reservoir that is attached to a linear actuator which is programmed with a software. A dedicated test bed was fabricated for the calibration of the device and for the in vitro analysis. A concentration pro le with regards to the time is con- structed to modify the amount of drug delivery according to our needs. This wearable device provides drug dosage for topical applications especially for wounds and presents many advantages over traditional delivery systems in- cluding accurate and speci c dose delivery, improved medication compliance and therapeutic outcomes, patient monitoring, and reduced side e ects.