Dexamethasone on loaded transfersomes nanoparticles for skin delivery

Abstract

Transdermal drug delivery system (TDDS) serves as excellent route to reach the target site efficiently. However, its use is limited because of the barrier stratum corneum, the top layer of skin. Transfersomes have the ability to evade these barriers because they are highly deformable making them stress-responsive and stress-adaptive complexes. The basic aim of the study was to develop nano-deformable transfersomes (NDTs) nanoparticles for the dermal delivery of Dexamethasone against burn wounds. NDTs were formulated by a modified thin film hydration method. They were composed of phosphatidylcholine and Tween 80, and loaded with anti-inflammatory drug dexamethasone. The physicochemical properties of DM-loaded transfersomes were established in terms of vesicle size and entrapment efficiency. DM-loaded transfersomes were entrapped within Carbopol gel network for the ease of topical application. The in vivo results displayed higher anti-inflammatory activity by efficiently healing burn wounds. Precisely, the outcomes indicated that the efficient delivery of DM could be accomplished by using topically applied transfersomes for the treatment of burn wounds as compared to simple DM gel formulation.