Ciprofloxacin Loaded Gold Nanoparticles for the Eradication of Enterococcus faecalis in Liver and Kidney of Mice

Abstract

The availability of diverse nanoparticles with controlled properties has generated widespread interest in their use in biological systems. Gold nanoparticles are widely used in the biomedical field because of their large surface area, and high conductivity. The modification of the nanometers is conducted to enhance the interaction of these nanoparticles with biological cells. Enterococcus faecalis a well know pathogen that causes nosocomial infection. It also shows multidrug resistance. This research includes the synthesis of gold nanoparticles then drug loading. After this different characterization techniques (UV-Vis, FTIR, SEM, Zeta potential, stability tests, etc.) were done to check these drugs loaded gold nanoparticles. Then evaluate the effect of an antibiotic Ciprofloxacin and its gold nanoparticles on Enterococcus faecalis. Study shows that metal nanoparticles could be useful carriers for ciprofloxacin, and ciprofloxacin loaded gold nanoparticles are stable. The bound ciprofloxacin is fluorescent, and this property could be used in biological investigations and they together are more effective in eradicating Enterococcus faecalis in the liver and kidney of mice.