Administration of Fluoxetine incorporated Liposomal Nanoparticles in the treatment of Learned Helplessness model of Depression

Abstract

Depression is one of the common leading mental health disorders that does not have a specific criterion of symptoms but negatively affects a persons’ mood, way of thinking and living. According to WHO few symptoms of depression can be described as sadness, loss of interest, being miserable, or suicidal thoughts. Depression is treatable with a number of different kind of antidepressants but sometimes these antidepressants can cause more adverse effect rather than treating the depression, blood brain barrier is one of the main hindrance that antidepressants face, it’s a semipermeable membrane separating the blood from the cerebrospinal fluid that doesn’t let certain molecules or drug pass through blood brain barrier hence certain antidepressants fail to work. The aim of this research was to see the effects of fluoxetine and fluoxetine incorporated DPPCnanoparticles in Learned Helplessness mice model of depression. Peg coated and uncoated Fluoxetine incorporated Liposomal nanoparticles using DPPC, cholesterol, PEG 6000 were made via Thin Film Hydration method. Nanoparticles were subjected to characterizations before being injected into the depressed mice via intravenous route. This research concludes that liposomal nanoparticle containing fluoxetine can be an effective for treatment of depression with lesser side effects than only fluoxetine. Therefore, these liposomal nanoparticles could be an effective way to treat depression with lesser side effects and having early onset of action.