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Now showing items 1-20 of 159

Combine ligand and structure based methodologies to probe stereo-selectivity of CYP3A4 inhibitors

Mukhtar, Sadia (Research Centre for Modeling and Simulation, (RCMS), 2015)

Cytochrome P450 (CYP-P450) enzymes play critical role in the metabolic processes of the body. These microsomal proteins are involved in the breakdown and detoxification of various xenobiotics, nutrients and clinically ...
Annotating the genomic variants in Next Generation Sequencing data through computational approach

Noureen, Mehwish (Research Centre for Modeling and Simulation, (RCMS), 2016)

Next Generation Sequencing (NGS) has made possible the parallel analysis of sequencing data. Different NGS platforms are generating huge amount of data. This data undergoes different analysis pipeline depending upon the ...
2D, 3D-QSAR and Docking studies on inhibitors of IR and IGF-1R: Exploration of binding mode at Tyrosine Kinase Domain

Pasha, Mustafa Kamal (RCMS NUST, 2016-06-28)

Insulin like growth factor-1 receptor (IGF-1R) along with highly homologous insulin receptor IR is integral component of cell proliferation, growth and survival and apoptosis protection. However, overexpression of IGF-1R ...
Computational Modeling and Analysis of Non-Small Cell Lung Cancer (NSCLC) Pathway using Static Analysis Approach to Identify Potential Biomarkers and Drug Targets

Hayat, Yawar (RCMS NUST, 2018-10-02)

Latterly, a vital prototype shift has been manifested in the management of non-small cell lung Cancer (NSCLC). Owing to the fact that NSCLC could be sub-categorized on the basis of its physiological morphology along with ...
Computational Modeling of coronary blood flow in 3D: An insight into the mechanical environment of atherosclerosis; using Image based FE – Modeling and Fluid Structure Interaction (FSI).

FAROOQ, NABISHA (RCMS NUST, 2018-10-12)

Coronary heart disease (CHD) is characterized by the narrowing of coronary arteries and is one of the leading causes of death in today’s century. The main cause of CHD is atherosclerosis jots down to the deposition of fat, ...
Computational Modeling and Analysis of Hepatitis C Pathway using Static Analysis Approach to Identify Critical Biomarkers and Drug Targets for Effective Diagnosis

Jadoon, Maryam (RCMS NUST, 2018-11-12)

Hepatitis C Virus is the vital etiological agent of one of the fatal diseases Hepatitis, leading towards hepatic infiltration with fats known as steatosis followed by fibrosis, cirrhosis, HCC hepatocellular carcinoma and ...
Identification of Biomarkers in Cutaneous Squamous Cell Carcinoma (cSCC) and Psoriasis via Computational Approaches

Sidra Adil (RCMS, National University of Sciences and Technology, 2019)

Cutaneous Squamous Cell Carcinoma is the second most common prevalent skin cancer all over the world with potential to metastasize and recur. There is an urge to discover biomarkers for cutaneous Squamous Cell Carcinoma ...
Therapeutic Target Identification for Gastric Carcinoma caused by Helicobacter pylori through Integrated Analysis of Microarray and RNA-Seq

Sabaoon Zeb (RCMS, National University of Sciences and Technology, 2019)

Gastric cancer (GC) is the third leading cause of death worldwide where major precursor of cancer progression is infection with gastric pathogen Helicobacter pylori. 50% of the world population is infected with H.pylori ...
Parameters Estimation of Biological Regulatory Networks: An Alternate Approach Based on Computation of Network Centrality

Darrak Moin Quddusi (RCMS, National University of Sciences and Technology, 2019)

Biological systems are complex, diverse and dynamic in nature and these features make them difficult to study. Thus, an easy way is to abstract them in the form of sim ple regulatory networks. Qualitative modeling approaches ...
UNDERSTANDING HOW GALAXIES ACQUIRE THEIR ANGULAR MOMENTUM USING NUMERICAL SIMULATIONS

Sara Zahoor (RCMS, National University of Sciences and Technology, 2019)

Using N-body cosmological simulation, we present a detail study of redshift evolution and the impact of box size on the properties of dark matter halos. Our focus is to review their structural parameters in ΛCDM model. ...
Integrated Structure- and Ligand-Based Pharmacoinformatic Protocol for the Modulation of Monoamine Oxidase B (MAO-B) in Parkinson’s disease

Rahma Qadeer (RCMS, National University of Sciences and Technology, 2019)

Oxidative stress is a phenomenon associated with various neurodegenerative diseases. Death of dopaminergic neurons in the substantia nigra is a major implication of Parkinson disease which occurs as a consequence of ...
Combined Ligand and Structure Based Studies to Design Potential Modulators of Insulin like Growth Factor 1 Receptor (IGF-1R) in Breast Cancer

Mehreen Liaqat (RCMS, National University of Sciences and Technology, 2019)

Insulin like growth factor (IGF) signaling system plays a critical role in regulating many physiological processes such as cellular growth, transformation and apoptosis. IGF-1 receptor (IGF-1R) plays a crucial role in ...
Analysis of Flaviviridae to find differentially expressed genes and potential inhibitors through different in silico techniques of “Next Generation Sequencing” and “polypharmacology” approach

Samawia Rizwan (RCMS, National University of Sciences and Technology, 2019)

Flaviviridae is a family of RNA viruses which have small envelop. Most of the flaviviruses are host-specific. This study focus on Dengue, Zika, West Nile and Japanese encephalitis viruses. These are arthropod-borne viruses ...
Microarray and RNA-seq Analysis of RNA and miRNA Expressions in Hepatocellular Carcinoma: Connection between Onset and Inhibition

Saddia Bano (RCMS, National University of Sciences and Technology, 2019)

Hepatocellular Carcinoma (HCC) becomes the life threatening disease around the world. There are many factors like inflammation and fibrogenic tissues in liver that leads the patient towards advanced liver fibrosis and ...
Molecular Modeling Strategies to Probe Modulation of NADPH Oxidase 2 (NOX2) in Ischemic Stroke

Sadaf Ijaz (RCMS, National University of Sciences and Technology, 2019)

Excessive amounts of reactive oxygen species (ROS) may contribute to oxidative stress which is the fundamental mechanism of cell-damaging in cerebral ischemic stroke. NADPH oxidases 2 (NOX2) being the primary cause of ...
Computational Design and Study of a Series of Compounds as Potential Ribosomal S6 Kinase Inhibitors with Reduced Side Effects

Naseem, Khansa ((Research Center For Modeling and Simulation(RCMS)., 2019)

Cancer is a disease where abnormal multiplication of cell occur, Different types of cancer such as lung cancer, breast cancer, colon cancer are causing large number of deaths of human. Kinases are proteins involved in ...
3D-QSAR Guided Design, Biological Evaluation and Lead Optimization of Promising Inhibitors of the Multidrug Resistance Transporter P-glycoprotein (P-gp)

Iftkhar, Saba (RCMS NUST., 2019-03-02)

Multidrug resistance (MDR) is a phenomenon associated with resistance of cancer cells to a wide range of structurally and functionally diverse group of drugs thus, contributes as major constituent against chemotherapeutics ...
Structure Based Approaches to Probe Binding Hypothesis of Mutant p53 Modulators

Fazal, Mahjabeen (RCMS NUST, 2019-03-11)

p53 is a tumor suppressor gene that is involved in normal cell growth and perform its normal physiological function by responding to DNA damage via activation of DNA repair genes thus, inducing apoptosis and in turns ...
Combined Ligand and Structure Based Studies to Design Potential Modulators of Insulin like Growth Factor 1 Receptor (IGF-1R) in Breast Cancer

Liaqat, Mehreen (RCMS NUST, 2019-03-28)

Insulin like growth factor (IGF) signaling system plays a critical role in regulating many physiological processes such as cellular growth, transformation and apoptosis. IGF-1 receptor (IGF-1R) plays a crucial role in ...
Pharmacoinformatics Approaches to Probe Current Paradigm Shift in Hypercholesterolemia

Naeem, Sahar (RCMS NUST, 2019-04-07)

Statins (hydroxymethyl-glutaryl coenzyme A reductase inhibitors) is well known for its activity to reduce “bad” low density lipoprotein (LDL) cholesterol concentrations and cardiovascular risk. Therefore, Statins therapy ...

Now showing items 1-20 of 159

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