The iRhoms are part of the rhomboid family, highly conserved among all sequenced metazoans. However, they are known as pseudoproteases as they lack vital amino acid residues required for the catalysis of serine proteases. ...

Alternative splicing (AS) generates various structurally and functionally different protein isoforms. AS plays an important role in cancers by triggering hallmarks of cancer from a progression of primary tumour cells ...

The gut microbiome is a complex ecosystem of microorganisms that reside in the gastrointestinal tract (GIT). The interaction between the gut microbiota and the brain is often called the microbiota/gut-brain axis, which ...

Autism Spectrum Disorder (ASD) represents a neurological condition characterized by deficits in social communication, social interaction, and the presence of restricted and repetitive behaviors. The diagnosis of ASD has ...

Autism Spectrum Disorder (ASD) is a neurological disorder marked by difficulties with social interaction, repetitive behavioral patterns, and constrained hobbies and interests. This lifelong disorder begins in early childhood ...

Advancements in artificial intelligence over the last decade have transformed numerous fields, including biotechnology. Recent developments in deep learning (DL) have led to the creation of models capable of generating ...

Leukemia is a cancer of white blood cells and body's blood forming tissues, including the bone marrow and the lymphatic system. It is ranked at 5th position in Pakistan with a prevalence rate of 4.2%. Late diagnosis of ...

Kinases are one of the many enzymes that are absolutely essential for the regulation of cell division and in the performance of so many actions in the cell. They are implicated with many diseases, most notably cancer, ...

CAR T cell therapy has emerged as a promising approach for treating various forms of cancer. Despite its success, the effectiveness of CAR T cell therapy can be influenced by the specific configurations of signaling ...

Cytochrome P450 (CYP-P450) enzymes play critical role in the metabolic processes of the body. These microsomal proteins are involved in the breakdown and detoxification of various xenobiotics, nutrients and clinically ...