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MS: Recent submissions

Now showing items 81-100 of 159

Molecular Modeling Strategies to Probe Stereoselectivity of HIV Protease Inhibitors

Dilnawaz, Rabab (RCMS NUST, 2019-06-08)

HIV being the etiologic agent of AIDS remains one of the standstill challenges all over the world from the past few decades. During HIV replication, HIV protease plays a critical role in splitting a polyprotein precursor ...
Pharmacoinformatics Protocol to Predict the Modulators of ABL & SRC for the Chemotherapeutic Treatment of Helicobacter Pylori Induced Gastric Cancer

Akbar, Naveed (RCMS NUST, 2020-12-09)

Gastric cancer is an aggressive universal disease that impose a daunting impact on global health burden. Helicobacter Pylori is mainly considered the robust risk factor in the progression of gastric cancer. The oncoprotein ...
Combined Machine Learning and Pharmaco-informatics Guided Protocol for the Virtual Screening of New Chemical Entities against Hepatocellular Carcinoma

Jadoon, Maharij Haroon (RCMS NUST, 2021-01-03)

Hepatocellular carcinoma (HCC) is one of the most prevalent worldwide cancer. Various studies reported that chronic infections with hepatitis B virus (HBV) or hepatitis C virus (HCV), reactivation of telomerase expressions, ...
Computational Modeling and Analysis of Hepatitis C Pathway using Static Analysis Approach to Identify Critical Biomarkers and Drug Targets for Effective Diagnosis

Jadoon, Maryam (RCMS NUST, 2018-11-12)

Hepatitis C Virus is the vital etiological agent of one of the fatal diseases Hepatitis, leading towards hepatic infiltration with fats known as steatosis followed by fibrosis, cirrhosis, HCC hepatocellular carcinoma and ...
Comparison of Differentially Expressed Genes to Identify Potential Targets of Neurodegeneration using Bioinformatics Approach

Hamid, Maham (RCMS NUST, 2020-09-06)

Neurodegeneration is termed as the loss of structure or function of neurons that contributes to the death of neurons. Neurological and neuropsychological signs and symptoms of a particular disease depends upon the site ...
Investigating the Anti-Herpes Simplex Virus-2 Potential of Phytochemicals Obtained from Polygonum aviculare

Sabahat Butt, Razmia (SINES NUST, 2023-08-02)

Genital herpes is a sexually transmitted infection, caused by Herpes Simplex Virus-2. The virus is transmitted through body fluids and causes lesions and ulcers of the skin. The virus has the ability to cause secondary ...
Co-expression analysis of gene expression data to explore the differential expression network of a-synuclein in Parkinson’s disease

Hanif, Ayesha (RCMS NUST, 2020-03-01)

Parkinson’s disease(PD) is the 2nd most common neurodegenerative disease which is characterised by motor and non-motor symptoms including muscle movement, learning and speech. PD starts from Substantia Nigra (SN) in the ...
Modelling and Construction of Pan-genome of Plasmodium Species: A Region Wise Analysis

Riaz, Farhana (RCMS NUST, 2021-09-05)

Malaria, a mosquito-borne disease, continues to be a global health problem due to antibiotic resistance and mutations by host and environmental factors. It is caused by a single cell protozoan known as Plasmodium, of which ...
Combined Ligand and Structure Based Studies to Design Potential Modulators of Insulin like Growth Factor 1 Receptor (IGF-1R) in Breast Cancer

Liaqat, Mehreen (RCMS NUST, 2019-03-28)

Insulin like growth factor (IGF) signaling system plays a critical role in regulating many physiological processes such as cellular growth, transformation and apoptosis. IGF-1 receptor (IGF-1R) plays a crucial role in ...
RNA Seq Analysis Of Triple Negative Breast Cancer Cells Lines For The Identification of Common Therapeutic Targets

Jamil, Afifa (SINES NUST., 2021-10-01)

Triple Negative Breast cancer (TNBC) is a heterogeneous disease that is oestrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 negative based on immunohistochemistry. TNBC is distinguished ...
3D-QSAR Guided Design, Biological Evaluation and Lead Optimization of Promising Inhibitors of the Multidrug Resistance Transporter P-glycoprotein (P-gp)

Iftkhar, Saba (RCMS NUST., 2019-03-02)

Multidrug resistance (MDR) is a phenomenon associated with resistance of cancer cells to a wide range of structurally and functionally diverse group of drugs thus, contributes as major constituent against chemotherapeutics ...
Development of Deep Learning pipeline for Airways Segmentation in Human lungs

Batool, Shakra (SINES-NUST., 2023-07-12)

Chronic respiratory diseases cause abnormality in the lungs, especially the airways, and are the reason for mortality around the world. These problems are more common in low and middle-income countries where resources ...
COMPARATIVE ANALYSIS OF ALPHAFOLD2 & ESMFOLD ALGORITHMS TO SUPPORT BIOSIMILARITY & DRUG DISCOVERY

Mariam, Zamara (SINES NUST., 2023-07-12)

The elucidation of three-dimensional protein structure plays a pivotal role in comprehending biological phenomena. It directly governs protein function and hence aids in drug discovery. Development of protein prediction ...
Identification of Potential Biomarkers through Multi-omics approach for Hepatocellular Carcinoma

Ali, Zafar (SINES NUST., 2023-07-05)

Hepatocellular carcinoma (HCC) is a form of liver malignancy that accounts for roughly about 90 percent of all liver cancer cases. Due to its asymptomatic early stages, HCC is a difficult and complex disease to manage, ...
Single-Cell RNA Sequencing Reveals a Comprehensive Cellular Atlas of Primary Lung Adenocarcinomas and its Metastatic Sites

Ahmad, Rizwan (SINES-NUST., 2023-05-23)

Lung adenocarcinoma (LUAD) is the most common type of lung cancer and a leading cause of cancer-related mortality worldwide. LUAD exhibits high heterogeneity and complexity at both molecular and cellular levels and ...
Machine Learning Models to Probe the CYP3A4 Mediated Drug Metabolic Profile

Mian, varda (SINES NUST., 2022-10-23)

Cytochrome P450s (CYP) are a diverse group of Heme-containing proteins found in all kingdoms of life, that participate in vital life processes including oxidization of endogenous and exogenous compounds. Of the 57 CYP ...
Probing the Mechanistic and Therapeutic Intervention for the Drug Induced Age Reverse Procedure

Rana, Marvah Mehmood (SINES NUST., 2022-09-06)

Telomeres protect chromosomal ends during cell replication. Cell division shortens telomeres, causing senescence, differentiation, or necrosis and eventually aging. Aging caused by telomeres shortening is linked to ...
Machine Learning Models for the Prediction of Ejection Fraction of Left Ventricle in Coronary Heart Disease

Sarfraz, Mian Talha (SINES NUST., 2022-09-06)

Coronary heart disease includes the formation of plaque around the walls of arteries of heart. That causes the arteries to be tightened and restricts the flow of blood inside the artery. The left ventricle is the main ...
Identification and Modeling of Significant External Factors Causing Bovine Mastitis in Cows using ML Methods

Iqbal, Maliha (SINES NUST., 2022-10-06)

Bovine mastitis is a condition in which mammary gland has inflammation and the major causative agent is bacterial infection. Microbes usually cause mastitis when they enter teat through teat canal. Streptococci, ...
Computational Analysis of Gene Expression Pattern and Identification of Potential Therapeutics Against Malignant Pleural Mesothelioma: Hybrid Approach of NGS, Microarray and Virtual Screening

Baksh, Muqadas (SINES-NUST., 2022-10-01)

Malignant pleural mesothelioma (MPM) arises in the lining of lungs. MPM shown non-specific symptoms at early stages. Mostly, the pleura is affected by expo- sure of asbestos. According to different studies, many factors ...

Now showing items 81-100 of 159

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