Molecular Modeling Protocol for the Virtual Screening of Inhibitors of c-Myb for Therapeutic Treatment of β- Hemoglobinopathies

Abstract

"But Allah guides whom He wills. And He is most knowing of the [rightly] guided" Quran (28:56). We are indebted to Allah to enable us with the knowledge to complete this project. He is the only true guider and on whom we rely on all matters. My sincere respect goes to my supervisor Dr. Ishrat Jabeen who has been an important guidance throughout this project. I pay my regards to her for her precious advice and time during my work. I could not have imagined having a better advisor and mentor for my study. I would also like to thank my guidance committee members: Dr. Zamir Hussain and Dr. Tariq Saeed from RCMS, NUST for their encouragement and insightful comments. I would like to thank all the faculty members and lab assistants at RCMS, NUST. I am indebted to my family for their everlasting love and care to me. I am really pleased to pay my special regards to them for their love and support. Without their motivation, I would’ve not completed this project. Their limitless prayers are the roots of my hard work and I owe my special regards to them. Last, but not the least, special thanks to my friend Ammara Naz, Rijja Hussain, Syeda Aniqa Bukhari, Maham Ahmed and Mehrosh Agha for creating such positive and learning environment in the lab. I am also thankful to my colleagues Mariya Ehsan, Fatima Iqbal, Aqsa Khalid, Humaira Ismatullah, and Maharij Jadoon for the scientific discussions and guiding me in every possible way.