Abstract:
Nodal regions, areas of intensive contact between Schwann cells and axons, may be
exceptionally vulnerable to Diabetes-induced changes because they are exposed to and
impacted by the metabolic implications of Diabetes. Insulin receptors, glucose
transporters, Na+ and K+ channels, and mitochondria are abundant in nodes, all of which
have been linked to the development and progression of Diabetic Peripheral Neuropathy
(DPN). We gave natural herbs i.e., Nigella sativa and Cassia angustifolia to
hyperglycemic mice after STZ injections to check their potential in preventing DPN. We
saw improvements in demyelination, neuronal loss, and oxidative stress despite sustained
hyperglycemia. We investigated the expression of MPZ and NFL in sciatic nerve and
brain tissue samples from STZ-induced Type 1 Diabetes Mellitus (T1DM) mice models
and compared control and dose-administered groups to diseased groups. Statistical
analysis revealed a significant difference between diabetic mice and mice who were
given herbs upon the induction of disease. The findings indicate that including these
herbs in the diets of diabetic as well as pre-diabetic patients can reduce complications
associated with T1DM, notably diabetic peripheral neuropathy.
