Effects of Cassia Angustifolia and Nigella Sativa for the prevention of Diabetic Neuropathy

Abstract

Nodal regions, areas of intensive contact between Schwann cells and axons, may be exceptionally vulnerable to Diabetes-induced changes because they are exposed to and impacted by the metabolic implications of Diabetes. Insulin receptors, glucose transporters, Na+ and K+ channels, and mitochondria are abundant in nodes, all of which have been linked to the development and progression of Diabetic Peripheral Neuropathy (DPN). We gave natural herbs i.e., Nigella sativa and Cassia angustifolia to hyperglycemic mice after STZ injections to check their potential in preventing DPN. We saw improvements in demyelination, neuronal loss, and oxidative stress despite sustained hyperglycemia. We investigated the expression of MPZ and NFL in sciatic nerve and brain tissue samples from STZ-induced Type 1 Diabetes Mellitus (T1DM) mice models and compared control and dose-administered groups to diseased groups. Statistical analysis revealed a significant difference between diabetic mice and mice who were given herbs upon the induction of disease. The findings indicate that including these herbs in the diets of diabetic as well as pre-diabetic patients can reduce complications associated with T1DM, notably diabetic peripheral neuropathy.