NANOMATERIALS-BASED THERANOSTIC PLATFORM FOR CANCER TREATMENT USING ULTRASONIC HYPERTHERMIA

Abstract

Cancer is amongst the most complex global health issues which continues to demand serious action. Several treatments including chemotherapy, radiotherapy, and surgery are being practiced but they have multiple limitations. The side effects of these therapies include the death of healthy cells ultimately resulting in hair loss, nail damage, and skin burns. Nanotechnology has played a crucial role in tackling these issues and nanomaterials based ultrasonic hyperthermia bypasses some of these side effects and can treat cancer. In the present study, Magnetite and Cobalt doped magnetite nanoparticles were synthesized via co-precipitation route. Cobalt concentration of x = 0.7 was used as maximum magnetization is reported at this amount. Calcination was done to remove moisture and impurities from the samples. These synthesized nanoparticles were characterized by XRD, SEM, EDX, and FTIR for evaluating crystal structure, phase purity, morphology, composition, and functional groups, respectively. The findings confirmed the successful synthesis of magnetite as well as the doping of cobalt via XRD, EDX, and FTIR. SEM results confirmed the spherical morphology for both samples. Agglomeration was also observed due to the magnetic nature of nanoparticles. Furthermore, time-temperature analysis was studied using probe sonication in which a temperature increase of 11°C, from 26°C to 37°C, was observed for all four samples which included (1) De-ionized water and Cobalt doped magnetite nanoparticles, (2) De-ionized water, Cobalt doped magnetite nanoparticles and Bacteria (3) De-ionized water, Cobalt doped magnetite nanoparticles and Rose Bengal (4) De-ionized water, Cobalt doped magnetite nanoparticles, Rose Bengal and Bacteria. Finally, a setup was designed to study the temperature behavior of nanoparticles in response to ultrasound in future.