Abstract:
The improved biomimetic coatings for titanium-based implants have attracted a lot of
attention concerning their potential to improve osseointegration and lower the risk of infection.
The production, characterisation, and use of DEAE-Dextran silver nanoparticles (AgNPs) as a
novel biomimetic covering for titanium-based hard tissue implants are the subjects of this
thesis. The DEAE-Dextran, a biocompatible polymer, serves as both a stabilizing and
functionalizing agent, facilitating the homogeneous dispersion of AgNPs on the titanium
surface. The study employs a comprehensive experimental approach, including chemical
synthesis, surface characterization, and in vitro biological assessments. Characterization
methods include fourier transform infrared (FTIR), Zeta potential, X-ray diffraction (XRD),
raman spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, and scanning electron
microscopy (SEM). Results indicate that the DEAE-Dextran silver nanoparticle coating
exhibits a uniform and stable layer on the titanium substrate, with significant antimicrobial
activity against Staphylococcus aureus. The study concludes that DEAE-Dextran AgNPs-based
coatings present a promising approach for enhancing the performance of titanium-based
implants, offering a dual function of infection prevention and improved biocompatibility. This
work contributes to the field of biomaterials by providing a novel coating strategy that
combines the mechanical robustness of titanium with the biological functionalities of DEAEDextran and silver nanoparticles, potentially leading to improved clinical outcomes in
orthopedic and dental implant applications.
