DEAE-Dextran silver nanoparticles-based biomimetic coating for titanium-based hard tissue implant applications

Abstract

The improved biomimetic coatings for titanium-based implants have attracted a lot of attention concerning their potential to improve osseointegration and lower the risk of infection. The production, characterisation, and use of DEAE-Dextran silver nanoparticles (AgNPs) as a novel biomimetic covering for titanium-based hard tissue implants are the subjects of this thesis. The DEAE-Dextran, a biocompatible polymer, serves as both a stabilizing and functionalizing agent, facilitating the homogeneous dispersion of AgNPs on the titanium surface. The study employs a comprehensive experimental approach, including chemical synthesis, surface characterization, and in vitro biological assessments. Characterization methods include fourier transform infrared (FTIR), Zeta potential, X-ray diffraction (XRD), raman spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, and scanning electron microscopy (SEM). Results indicate that the DEAE-Dextran silver nanoparticle coating exhibits a uniform and stable layer on the titanium substrate, with significant antimicrobial activity against Staphylococcus aureus. The study concludes that DEAE-Dextran AgNPs-based coatings present a promising approach for enhancing the performance of titanium-based implants, offering a dual function of infection prevention and improved biocompatibility. This work contributes to the field of biomaterials by providing a novel coating strategy that combines the mechanical robustness of titanium with the biological functionalities of DEAEDextran and silver nanoparticles, potentially leading to improved clinical outcomes in orthopedic and dental implant applications.