Abstract:
Background:
Enterococcus Fecalis is a very well known pathogen that causes nosocomical infections. It is
also known for its multidrug resistance. Similarly, the Escherchia coli is a known bacteria of
human intestine. In normal conditions, the strains of E.coli are harmless but some harmful strains
can cause severe food poisoning to the humans. The aim of this research is to evaluate the effect
of an antibiotic Ciprofloxacin and its gold nanoparticles on these bacterias.
Ciprofloxacin is the antibiotic that is being used against the infections caused by various Gram
positive and Gram negative bacteria. The gold nanoparticles are synthesized by the chemical
reduction method and then capped by the ciprofloxacin to make it functional for use. The invitro
hemolytic activity of the ciprofloxacin loaded gold nanoparticles was checked after the synthesis.
Results:
The ciprofloxacin loaded gold nanoparticles were characterized using different techniques. The
size and shape was determined by the SEM and UV-Vis was used to check the synthesis. The
drug loaded particles were found stable and it showed enhanced activity than the parent drug on
the bacterial colonization.
