Synthesis and Characterization of the Ciprofloxacin Loaded Gold Nanoparticles

Abstract

Background: Enterococcus Fecalis is a very well known pathogen that causes nosocomical infections. It is also known for its multidrug resistance. Similarly, the Escherchia coli is a known bacteria of human intestine. In normal conditions, the strains of E.coli are harmless but some harmful strains can cause severe food poisoning to the humans. The aim of this research is to evaluate the effect of an antibiotic Ciprofloxacin and its gold nanoparticles on these bacterias. Ciprofloxacin is the antibiotic that is being used against the infections caused by various Gram positive and Gram negative bacteria. The gold nanoparticles are synthesized by the chemical reduction method and then capped by the ciprofloxacin to make it functional for use. The invitro hemolytic activity of the ciprofloxacin loaded gold nanoparticles was checked after the synthesis. Results: The ciprofloxacin loaded gold nanoparticles were characterized using different techniques. The size and shape was determined by the SEM and UV-Vis was used to check the synthesis. The drug loaded particles were found stable and it showed enhanced activity than the parent drug on the bacterial colonization.