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MS: Recent submissions

Now showing items 121-140 of 159

Using Machine Learning Algorithms to predict Sepsis and its stages in ICU patients

Ghais, Nimrah (SINES NUST, 2022-01-06)

Sepsis is blood poisoning disease that occurs when body shows dysregulated host response to an infection and cause organ failure or tissue damage which may increase the mortality rate in ICU patients. As it becomes major ...
Examining the Therapeutic Efficacy of Glucocorticoids using Machine Learning Based Transcriptomic Target Profiling in Autoimmune Diseases

Amjad, Maheera (SINES NUST, 2022-03-06)

Immune system protects human body from infections or foreign entities through a well organised mechanism but sometimes autoimmunity is activated. Autoimmune disorders such as posriasis, multiple sclerosis, systematic ...
Combined Ligand and Structure Guided Protocol for the Virtual Screening of Activators of NRF2-Associated Cellular Process in Cardiovascular Diseases.

Nisar, Nimra (SINES NUST, 2022)

NRF2 (NF-E2 p45-related factor 2) is a transcriptional factor that controls the production of antioxidant and cytoprotective enzymes that are produced in response to oxidative stress. NRF2 and its primary inhibitor, the ...
Investigating Isoform Switching in RHBDF2 for its Role in human Neoplastic Growth in Breast

Masood, Mehar (RCMS NUST, 2022-01-06)

Breast cancer is the second leading cause of cancer-related deaths globally, and its prevalence rates are increasing day by day. One major reason is the assumption that a “one gene leads to one protein” approach in most ...
ADAM9 Isoform Switching in Oesophageal Cancer

us Subha, Noor (RCMS NUST, 2021-09-01)

Alternative splicing (AS) generates various structurally and functionally different protein isoforms. AS plays an important role in cancers by triggering hallmarks of cancer from a progression of primary tumour cells ...
GUITAR - A Tkinter based desktop interface for transcriptomic analysis of RNA-Seq data; validation through case study of disease psoriasis

Rashid, Sidrah (RCMS NUST, 2021-09-06)

RNA-Seq has enabled the detection of novel transcripts and offers a genome wide analysis of gene fusions, single nucleotide variation and indels. This type of com- putational RNA-Seq analysis requires a researcher to ...
Integrated molecular modelling and machine learning strategies for the design of potential therapeutic agents against Neuroblastoma

Agha, Mehrosh (RCMS NUST, 2021-12-01)

Neuroblastoma is cancer that develops from immature nerve cells found in several areas of the body. It arises from undifferentiated sympathetic-adrenal lineage cells and is mostly intermittent. Intracellular calcium ion ...
Molecular Modeling Protocol for the Virtual Screening of Inhibitors of c-Myb for Therapeutic Treatment of β- Hemoglobinopathies

Rauf, Aiman (RCMS NUST, 2021-11-06)

"But Allah guides whom He wills. And He is most knowing of the [rightly] guided" Quran (28:56). We are indebted to Allah to enable us with the knowledge to complete this project. He is the only true guider and on whom ...
Integrated Machine Learning and Molecular Modelling Strategies to Probe Anti-inflammatory Response of New Chemical Entities

Hafiza Aliza Khan (RCMS, National University of Sciences and Technology, 2020)

5-lipoxygenase activating protein (FLAP) inhibitors have proven to attenuate 5-LO pathway activity and high leukotriene (LT) production that lead to chronic inflammation which is the root cause behind number of ...
Molecular Modeling Strategies to Probe Modulation of NADPH Oxidase 2 (NOX2) in Ischemic Stroke

Sadaf Ijaz (RCMS, National University of Sciences and Technology, 2019)

Excessive amounts of reactive oxygen species (ROS) may contribute to oxidative stress which is the fundamental mechanism of cell-damaging in cerebral ischemic stroke. NADPH oxidases 2 (NOX2) being the primary cause of ...
Integrated Structure- and Ligand-Based Pharmacoinformatic Protocol for the Modulation of Monoamine Oxidase B (MAO-B) in Parkinson’s disease

Rahma Qadeer (RCMS, National University of Sciences and Technology, 2019)

Oxidative stress is a phenomenon associated with various neurodegenerative diseases. Death of dopaminergic neurons in the substantia nigra is a major implication of Parkinson disease which occurs as a consequence of ...
Microarray and RNA-seq Analysis of RNA and miRNA Expressions in Hepatocellular Carcinoma: Connection between Onset and Inhibition

Saddia Bano (RCMS, National University of Sciences and Technology, 2019)

Hepatocellular Carcinoma (HCC) becomes the life threatening disease around the world. There are many factors like inflammation and fibrogenic tissues in liver that leads the patient towards advanced liver fibrosis and ...
Analysis of Flaviviridae to find differentially expressed genes and potential inhibitors through different in silico techniques of “Next Generation Sequencing” and “polypharmacology” approach

Samawia Rizwan (RCMS, National University of Sciences and Technology, 2019)

Flaviviridae is a family of RNA viruses which have small envelop. Most of the flaviviruses are host-specific. This study focus on Dengue, Zika, West Nile and Japanese encephalitis viruses. These are arthropod-borne viruses ...
Combined Ligand and Structure Based Studies to Design Potential Modulators of Insulin like Growth Factor 1 Receptor (IGF-1R) in Breast Cancer

Mehreen Liaqat (RCMS, National University of Sciences and Technology, 2019)

Insulin like growth factor (IGF) signaling system plays a critical role in regulating many physiological processes such as cellular growth, transformation and apoptosis. IGF-1 receptor (IGF-1R) plays a crucial role in ...
Identification of Biomarkers in Cutaneous Squamous Cell Carcinoma (cSCC) and Psoriasis via Computational Approaches

Sidra Adil (RCMS, National University of Sciences and Technology, 2019)

Cutaneous Squamous Cell Carcinoma is the second most common prevalent skin cancer all over the world with potential to metastasize and recur. There is an urge to discover biomarkers for cutaneous Squamous Cell Carcinoma ...
Therapeutic Target Identification for Gastric Carcinoma caused by Helicobacter pylori through Integrated Analysis of Microarray and RNA-Seq

Sabaoon Zeb (RCMS, National University of Sciences and Technology, 2019)

Gastric cancer (GC) is the third leading cause of death worldwide where major precursor of cancer progression is infection with gastric pathogen Helicobacter pylori. 50% of the world population is infected with H.pylori ...
UNDERSTANDING HOW GALAXIES ACQUIRE THEIR ANGULAR MOMENTUM USING NUMERICAL SIMULATIONS

Sara Zahoor (RCMS, National University of Sciences and Technology, 2019)

Using N-body cosmological simulation, we present a detail study of redshift evolution and the impact of box size on the properties of dark matter halos. Our focus is to review their structural parameters in ΛCDM model. ...
Parameters Estimation of Biological Regulatory Networks: An Alternate Approach Based on Computation of Network Centrality

Darrak Moin Quddusi (RCMS, National University of Sciences and Technology, 2019)

Biological systems are complex, diverse and dynamic in nature and these features make them difficult to study. Thus, an easy way is to abstract them in the form of sim ple regulatory networks. Qualitative modeling approaches ...
Evaluation of link between Diabetes and Cardiovascular Diseases through Gene Set Enrichment analysis

Saleem, Sadaf (RCMS NUST, 2020-09-06)

Diabetes is metabolic disorder that is characterized by hyperglycemia, resulting from defects of insulin secretions. Chronic diabetic conditions are associated with long term damage and dysfunctioning of certain organs ...
Analyzing high throughput sequencing data for gene expression profiles in Thyroid Carcinoma to predict effective therapeutic targets

Qureshi, Aqsa (RCMS NUST, 2020-09-01)

The most common endocrine tumor is thyroid carcinoma (TC). The clinical significance of thyroid carcinoma with respect to the recurrence of the disease state has been reviewed recently. Current therapy includes surgery ...

Now showing items 121-140 of 159

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